Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.41 |
| ▸ | ALPL | P05186 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | ILK | Q13418 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345942 | 0.77 | NPC1 (0.54) | KDM4ENPC1GAAHSD17B10L3MBTL1 | |
| SCHEMBL3346686 | 0.75 | P2RX7 (0.57) | NPC1ALPLP2RX7L3MBTL1ALOX5 | |
| SCHEMBL2614354 | 0.72 | NPC1 (0.64) | KDM4ENPC1GAAHSD17B10ALPL | |
| SCHEMBL27942525 | 0.70 | NPC1 (0.49) | KDM4ENPC1GAAHSD17B10L3MBTL1 | |
| SCHEMBL17485151 | 0.70 | MAPK11 (0.48) | HSD17B10CHEK2RORC | |
| SCHEMBL3340363 | 0.70 | ALPL (0.43) | KDM4ENPC1GAAHSD17B10PLA2G10 | |
| SCHEMBL14456078 | 0.69 | HSP90AA1 (0.50) | KDM4ENPC1GAAHSD17B10L3MBTL1 | |
| SCHEMBL2467682 | 0.69 | TAS1R3 (0.50) | KDM4EHSD17B10 | |
| SCHEMBL3782207 | 0.67 | ALDH1A1 (0.51) | — | |
| SCHEMBL4471895 | 0.67 | P2RX7 (0.57) | NPC1GAAALPLP2RX7L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | KDM4E 2591/4885NPC1 1906/4885GAA 3977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.