Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346505 | 0.87 | GRM5 (0.55) | GRM5CYP2D6CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL3347519 | 0.84 | GRM4 (0.46) | GRM5CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3347789 | 0.83 | GRM5 (0.49) | GRM5CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3346754 | 0.81 | GRM5 (0.45) | GRM5 | |
| SCHEMBL3347598 | 0.80 | GRM5 (0.58) | GRM5CYP1A2CYP2A6CYP3A4 | |
| SCHEMBL3346877 | 0.79 | GRM5 (0.52) | GRM5 | |
| SCHEMBL3346202 | 0.78 | GRM5 (0.57) | GRM5KCNH2 | |
| SCHEMBL3351686 | 0.78 | GRM5 (0.49) | GRM5KCNH2 | |
| SCHEMBL3346603 | 0.78 | GRM5 (0.41) | GRM5CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3346384 | 0.78 | GRM5 (0.43) | GRM5CYP2D6CYP1A2KCNH2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2013087808-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PYRAZOLOPYRIMIDME AND CYCLODEXTRIN | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-06-20 | — | — | WO | disclosed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |