Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351280 | 0.88 | GRM5 (0.47) | GRM5CYP11B1DYRK1ACYP17A1 | |
| SCHEMBL3346505 | 0.86 | GRM5 (0.55) | GRM5DYRK1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3346922 | 0.82 | GRM5 (0.39) | GRM5DYRK1ACYP11B2 | |
| SCHEMBL3345958 | 0.80 | GRM5 (0.52) | GRM5CYP1A2CYP3A4CYP2A6 | |
| SCHEMBL3347563 | 0.80 | GRM5 (0.36) | GRM5DYRK1A | |
| SCHEMBL3347568 | 0.78 | GRM5 (0.38) | GRM5 | |
| SCHEMBL3347295 | 0.78 | GRM5 (0.48) | GRM5DYRK1A | |
| SCHEMBL3346877 | 0.76 | GRM5 (0.52) | GRM5DYRK1A | |
| SCHEMBL3346603 | 0.76 | GRM5 (0.41) | GRM5DYRK1AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3347789 | 0.73 | GRM5 (0.49) | GRM5DYRK1AALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |