Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | NPR3 | P17342 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | LAP3 | P28838 | 1/20 | 0.38 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346257 | 1.00 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11NPR3 | |
| SCHEMBL561106 | 0.89 | NPR3 (0.42) | MAPK14MAPK13MAPK12MAPK11NPR3 | |
| SCHEMBL561107 | 0.89 | NPR3 (0.42) | MAPK14MAPK13MAPK12MAPK11NPR3 | |
| SCHEMBL2280856 | 0.86 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11NPR3 | |
| SCHEMBL2280854 | 0.86 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11NPR3 | |
| SCHEMBL3345198 | 0.85 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11NPR3 | |
| SCHEMBL3345202 | 0.85 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11NPR3 | |
| SCHEMBL2276180 | 0.81 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11NPR3 | |
| SCHEMBL2276175 | 0.81 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11NPR3 | |
| SCHEMBL3344769 | 0.78 | ACACB (0.41) | ACACBTPSAB1TPSD1TPSG1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043865-A1 | INHIBITORS OF HSP90 | CHROMA THERAPEUTICS LTD (GB) | 2010-04-22 | — | — | WO | disclosed |