Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27953661 | 0.74 | PDCD1LG2 (0.34) | CHRNB2CHRNA4PDCD1LG2CD274CHRM2 | |
| SCHEMBL2738028 | 0.73 | KDM4E (0.39) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL12074033 | 0.71 | IKBKB (0.36) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL19725720 | 0.70 | IKBKB (0.35) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL2737905 | 0.69 | ALDH1A1 (0.32) | MEN1KMT2APOLBIKBKBNR1H4 | |
| SCHEMBL2737992 | 0.69 | IKBKB (0.31) | IKBKBNR1H4 | |
| SCHEMBL2737987 | 0.69 | TSHR (0.42) | KMT2A | |
| SCHEMBL2737997 | 0.69 | IKBKB (0.39) | CHRNB2IKBKB | |
| SCHEMBL8689606 | 0.68 | IKBKB (0.35) | MEN1CYP2D6CYP2C19KMT2APOLB | |
| SCHEMBL5639792 | 0.68 | MEN1 (0.37) | MEN1CYP2D6CYP2C19KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010067233-A1 | 1,2,4 TRIAZOLO [4, 3 -A] [1,5] BENZODIAZEPIN-5 (6H) -ONES AS AGONISTS OF THE CHOLECYSTOKININ-1 RECEPTOR (CCK-IR) | PFIZER INC. (US) | 2010-06-17 | — | — | WO | disclosed |