Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346515 | 0.86 | DRD2 (0.44) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL15648532 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL2574724 | 0.82 | GCGR (0.41) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL27801748 | 0.79 | DRD2 (0.42) | KDM4EALDH1A1MAPK1NOTUMCHRM1 | |
| SCHEMBL20630517 | 0.77 | SLC7A5 (0.54) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL20630516 | 0.77 | SLC7A5 (0.54) | KDM4EALDH1A1MAPK1NOTUMDRD2 | |
| SCHEMBL3094168 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL6575361 | 0.75 | MAPT (0.44) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL6575357 | 0.75 | MAPT (0.44) | KDM4EALDH1A1MAPK1NOTUMTP53 | |
| SCHEMBL5018752 | 0.75 | NOTUM (0.53) | KDM4EALDH1A1MAPK1NOTUMCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| EP-2139881-A1 | QUINOLINES AND THEIR THERAPEUTIC USE | Argenta Oral Therapeutics Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008122784-A1 | QUINOLINES AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LIMITED (GB) | 2008-10-16 | — | — | WO | disclosed |