SCHEMBL334653

SCHEMBL334653

Nc1cccc2c1OC(F)(F)O2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.39
ADORA2A P29274 7/20 0.36
ATR Q13535 1/20 0.35
BACE1 P56817 2/20 0.33
HTR1A P08908 1/20 0.33
DRD2 P14416 1/20 0.33
HTR2A P28223 1/20 0.33
GPR3 P46089 1/20 0.33
CD44 P16070 1/20 0.32
CYP3A4 P08684 3/20 0.32
TSHR P16473 2/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
PTPN11 Q06124 1/20 0.32
FFAR4 Q5NUL3 1/20 0.32
PIK3CA P42336 1/20 0.31
ALOX15 P16050 1/20 0.31
CASP1 P29466 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL418853 0.83 CETP (0.33) CD44CYP3A4TSHRALDH1A1HPGD
SCHEMBL2666086 0.80 CD44 (0.34) CD44CYP3A4TSHRALDH1A1HPGD
SCHEMBL30677836 0.77 FFAR4 (0.37) MPOADORA2AATRBACE1HTR1A
SCHEMBL423294 0.75 ADORA2A (0.35) MPOADORA2ABACE1HTR1ADRD2
SCHEMBL5325701 0.75 MPO (0.33) MPOADORA2AATRHTR1ADRD2
SCHEMBL6264335 0.75 AHR (0.45) MPOHTR1ADRD2HTR2AGPR3
SCHEMBL18866953 0.75 ALDH1A1 (0.45) HTR1ACD44CYP3A4TSHRALDH1A1
SCHEMBL3151886 0.75 FFAR4 (0.34) MPOADORA2AATRHTR1ADRD2
SCHEMBL13551133 0.75 MPO (0.33) MPOADORA2AATRHTR1ADRD2
SCHEMBL978248 0.75 MPO (0.33) MPOADORA2AATRHTR1ADRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 311 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000027394-A1 ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE UNIVERSITY COLLEGE LONDON (GB) 2000-05-18 WO claimed
EP-0198797-A2 Parasiticide CIBA-GEIGY AG (CH) 1986-10-22 EP claimed
JP-5155879-A None JP disclosed
EP-4688751-A1 ANTIVIRAL HETEROCYCLIC COMPOUNDS Enanta Pharmaceuticals, Inc. (US) 2026-02-11 EP disclosed
US-20250368659-A1 Antiviral Heterocyclic Compounds ENANTA PHARM INC (US) 2025-12-04 US disclosed
US-12479842-B2 Pyrido[3,2-d]pyrimidine compounds uses thereof for treating a proliferative disease UNIVERSITE DE MONTREAL (CA) 2025-11-25 US disclosed
US-20250270207-A1 PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE UNIVERSITE DE MONTREAL (CA) 2025-08-28 US disclosed
US-12358921-B2 Antiviral heterocyclic compounds ENANTA PHARMACEUTICALS, INC. (US) 2025-07-15 US disclosed
WO-2025063272-A1 NICOTINAMIDE DERIVATIVE AND AGRICULTURAL AND HORTICULTURAL PLANT DISEASE CONTROL AGENT クミアイ化学工業株式会社 2025-03-27 WO disclosed
WO-2025036382-A1 SULFONAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海复宏汉霖生物医药有限公司 2025-02-20 WO disclosed
EP-4504707-A1 ANTIVIRAL HETEROCYCLIC COMPOUNDS Enanta Pharmaceuticals, Inc. (US) 2025-02-12 EP disclosed
US-4925840-A FUNGICIDES CIBA-GEIGY CORPORATION (US) 1990-05-15 US disclosed
EP-0198797-B1 PARASITICIDE CIBA-GEIGY AG (CH) 1990-01-31 EP disclosed
US-4859783-A INTERMEDIATE FOR PESTICIDES CIBA-GEIGY CORPORATION (US) 1989-08-22 US disclosed
US-4859783-A INTERMEDIATE FOR PESTICIDES CIBA-GEIGY CORPORATION (US) 1989-08-22 US disclosed
US-4859783-A INTERMEDIATE FOR PESTICIDES CIBA-GEIGY CORPORATION (US) 1989-08-22 US disclosed
US-4780551-A 2,3-(DIFLUOROMETHYLENEDIOXY)CINNAMONITRILE; FUNGICIDES CIBA-GEIGY CORPORATION (US) 1988-10-25 US disclosed
US-4722935-A 2,2-DIFLUORO-4-(2*,4*-DINITRO-6*-TRIFLUOROMETHYLANILINO)-1, 3-BENZODIOXOLE CIBA-GEIGY CORPORATION (US) 1988-02-02 US disclosed
US-4705800-A Difluorbenzodioxyl cyanopyrrole microbicidal compositions CIBA-GEIGY CORPORATION (US) 1987-11-10 US disclosed
EP-0206999-A2 Microbiocide compounds CIBA-GEIGY AG (CH) 1986-12-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250270207-A1 PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE BRAF, NRAS, KRAS MPO 4262/4885ADORA2A 2115/4885ATR 1158/4885
US-12358921-B2 Antiviral heterocyclic compounds ACE, HPRT1, ACE2 MPO 164/4885ADORA2A 1661/4885ATR 3370/4885
US-12479842-B2 Pyrido[3,2-d]pyrimidine compounds uses thereof for treating a proliferative disease BRAF, NRAS, DPYD MPO 4279/4885ADORA2A 2078/4885ATR 1166/4885
US-20250368659-A1 Antiviral Heterocyclic Compounds ACE, HPRT1, ACE2 MPO 164/4885ADORA2A 1661/4885ATR 3370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.