Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | FPR1 | P21462 | 1/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449051 | 0.84 | CYP1A2 (0.44) | TSHRALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL30515632 | 0.84 | CYP1A2 (0.44) | TSHRALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL79944 | 0.83 | FFAR1 (0.45) | TSHRFFAR1FFAR4CHRM2S1PR1 | |
| SCHEMBL10454531 | 0.80 | CYP3A4 (0.57) | TSHRFFAR1FFAR4CHRM2S1PR1 | |
| SCHEMBL27350792 | 0.80 | TSHR (0.48) | TSHRFFAR1FFAR4CHRM2S1PR1 | |
| SCHEMBL13520595 | 0.79 | CYP3A4 (0.65) | TSHRFFAR1FFAR4CHRM2S1PR1 | |
| SCHEMBL8307761 | 0.78 | TSHR (0.46) | TSHRFFAR1FFAR4CHRM2S1PR1 | |
| SCHEMBL8144729 | 0.78 | CYP2C19 (0.55) | TSHRFFAR1FFAR4CHRM2S1PR1 | |
| SCHEMBL30666154 | 0.78 | TSHR (0.62) | TSHRFFAR1FFAR4CHRM2S1PR1 | |
| SCHEMBL3644208 | 0.78 | TSHR (0.62) | TSHRFFAR1FFAR4CHRM2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117466790-B | Preparation method of alpha-sulfinylated carbonyl compound | 西北师范大学 | 2024-05-28 | — | — | CN | claimed |
| CN-117466790-A | Preparation method of alpha-sulfinylated carbonyl compound | 西北师范大学 | 2024-01-30 | — | — | CN | claimed |
| CN-103570489-B | Method for preparing cis-olefin from alkyne through copper catalysis | UNIV NORTHWEST A&F | 2015-06-24 | — | — | CN | claimed |
| CN-103570489-A | Method for preparing cis-olefin from alkyne through copper catalysis | UNIV NORTHWEST A&F | 2014-02-12 | — | — | CN | claimed |
| CN-117466790-B | Preparation method of alpha-sulfinylated carbonyl compound | 西北师范大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-117466790-A | Preparation method of alpha-sulfinylated carbonyl compound | 西北师范大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-111662147-B | Process for preparing diynes and analogues thereof | 清华大学 | 2021-08-10 | — | — | CN | disclosed |
| CN-111662147-A | Process for preparing diynes and analogues thereof | 清华大学 | 2020-09-15 | — | — | CN | disclosed |
| EP-3083617-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-11 | — | — | EP | disclosed |
| EP-3017307-B1 | 3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING | UNIV STRASBOURG (FR) | 2018-11-21 | — | — | EP | disclosed |
| US-10131626-B2 | 3-aryl propiolonitrile compounds for thiol labeling | UNIVERSITE DE STRASBOURG (FR) | 2018-11-20 | — | — | US | disclosed |
| US-20170210700-A1 | 3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2017-07-27 | — | — | US | disclosed |
| US-9663454-B2 | 3-aryl propiolonitrile compounds for thiol labeling | UNIVERSITE DE STRASBOURG (FR) | 2017-05-30 | — | — | US | disclosed |
| US-20160145199-A1 | 3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING | UNIVERSITE DE STRASBOURG (FR) | 2016-05-26 | — | — | US | disclosed |
| EP-3017307-A1 | 3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING | Université de Strasbourg (FR) | 2016-05-11 | — | — | EP | disclosed |
| CN-103570489-B | Method for preparing cis-olefin from alkyne through copper catalysis | UNIV NORTHWEST A&F | 2015-06-24 | — | — | CN | disclosed |
| WO-2015001117-A1 | 3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING | UNIVERSITE DE STRASBOURG (FR) | 2015-01-08 | — | — | WO | disclosed |
| CN-103570489-A | Method for preparing cis-olefin from alkyne through copper catalysis | UNIV NORTHWEST A&F | 2014-02-12 | — | — | CN | disclosed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10131626-B2 | 3-aryl propiolonitrile compounds for thiol labeling | PTMS, TST, PNN | TSHR 2315/4885FFAR1 4827/4885FFAR4 4685/4885 |
| US-20170210700-A1 | 3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING | PTMS, TST, PNN | TSHR 2315/4885FFAR1 4827/4885FFAR4 4685/4885 |
| US-20160145199-A1 | 3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING | PTMS, TST, PNN | TSHR 2315/4885FFAR1 4827/4885FFAR4 4685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.