SCHEMBL8307761

SCHEMBL8307761

Cc1ccccc1C#CCBr

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.46
GRM5 P41594 2/20 0.41
FFAR1 O14842 7/20 0.39
FFAR4 Q5NUL3 2/20 0.39
CHRM2 P08172 1/20 0.39
S1PR1 P21453 1/20 0.39
FPR1 P21462 1/20 0.39
FPR3 P25089 1/20 0.39
GPR183 P32249 1/20 0.39
APLNR P35414 1/20 0.39
GPR65 Q8IYL9 1/20 0.39
ACHE P22303 2/20 0.38
ALDH1A1 P00352 2/20 0.36
CYP1A2 P05177 2/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
CYP2E1 P05181 1/20 0.34
CYP2C8 P10632 1/20 0.34
CYP2D6 P10635 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27350792 0.80 TSHR (0.48) TSHRGRM5FFAR1FFAR4CHRM2
SCHEMBL8144729 0.78 CYP2C19 (0.55) TSHRGRM5FFAR1FFAR4CHRM2
SCHEMBL3346530 0.78 TSHR (0.46) TSHRGRM5FFAR1FFAR4CHRM2
SCHEMBL30666154 0.78 TSHR (0.62) TSHRGRM5FFAR1FFAR4CHRM2
SCHEMBL3644208 0.78 TSHR (0.62) TSHRGRM5FFAR1FFAR4CHRM2
SCHEMBL28365099 0.77 TSHR (0.54) TSHRGRM5FFAR1FFAR4CHRM2
SCHEMBL8305078 0.76 FFAR1 (0.40) FFAR1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL28535742 0.75 TSHR (0.43) TSHRGRM5FFAR1FFAR4CHRM2
SCHEMBL8302074 0.74 KCNH2 (0.44) TSHRGRM5FFAR1CHRM2ALDH1A1
SCHEMBL436732 0.74 MME (0.40) GRM5CHRM2ACHEIKBKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111662147-B Process for preparing diynes and analogues thereof 清华大学 2021-08-10 CN disclosed
CN-111662147-A Process for preparing diynes and analogues thereof 清华大学 2020-09-15 CN disclosed
EP-0749430-B1 THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS AMERICAN HOME PROD (US) 1999-08-25 EP disclosed
US-5605918-A SUBSTITUTED THIAZOLIDINE-2,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-02-25 US disclosed
US-5574051-A HYPOGLYCEMIC AMERICAN HOME PRODUCTS CORPORATION (US) 1996-11-12 US disclosed
WO-1995024400-A1 THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1995-09-14 WO disclosed