Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 2/20 | 0.70 |
| ▸ | PLAT | P00750 | 2/20 | 0.70 |
| ▸ | CTSL | P07711 | 2/20 | 0.70 |
| ▸ | CTSH | P09668 | 2/20 | 0.70 |
| ▸ | CTSS | P25774 | 2/20 | 0.70 |
| ▸ | CASP14 | P31944 | 2/20 | 0.70 |
| ▸ | CTSK | P43235 | 2/20 | 0.70 |
| ▸ | CASP6 | P55212 | 2/20 | 0.70 |
| ▸ | CTSZ | Q9UBR2 | 2/20 | 0.70 |
| ▸ | CTSB | P07858 | 1/20 | 0.70 |
| ▸ | CASP4 | P49662 | 1/20 | 0.70 |
| ▸ | CASP5 | P51878 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | IDH1 | O75874 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031260 | 0.85 | RAB9A (0.62) | CTSVPLATCTSLCTSHCTSS | |
| SCHEMBL3347831 | 0.82 | CTSS (1.00) | CTSVPLATCTSLCTSHCTSS | |
| SCHEMBL14600703 | 0.78 | RAB9A (0.75) | CTSVPLATCTSLCTSHCTSS | |
| SCHEMBL20938665 | 0.78 | RAB9A (0.75) | CTSVPLATCTSLCTSHCTSS | |
| SCHEMBL3503380 | 0.78 | RAB9A (0.80) | CTSVPLATCTSLCTSHCTSS | |
| SCHEMBL13326008 | 0.78 | RAB9A (0.75) | CTSVPLATCTSLCTSHCTSS | |
| SCHEMBL5029172 | 0.78 | RAB9A (0.70) | CTSVPLATCTSLCTSHCTSS | |
| SCHEMBL14294391 | 0.78 | RAB9A (0.62) | CTSVPLATCTSLCTSHCTSS | |
| SCHEMBL20402878 | 0.78 | PDE4A (0.82) | CTSSCTSKRAB9APDE4A | |
| SCHEMBL18557113 | 0.78 | PDE4A (0.82) | CTSSCTSKRAB9APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059418-A1 | SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS | THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059418-A1 | SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS | THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) | 2010-05-27 | — | — | WO | disclosed |