Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347364 | 0.85 | SCN5A (0.39) | GRM5PDGFRBKDRDDR1TGFBR1 | |
| SCHEMBL3347295 | 0.83 | GRM5 (0.48) | GRM5 | |
| SCHEMBL3348434 | 0.80 | GRM5 (0.54) | GRM5 | |
| SCHEMBL3347261 | 0.80 | GRM5 (0.47) | GRM5 | |
| SCHEMBL3346805 | 0.80 | DYRK1A (0.43) | GRM5FFAR1 | |
| SCHEMBL3346980 | 0.80 | GRM5 (0.49) | GRM5PDGFRBKDRKDM4EALDH1A1 | |
| SCHEMBL3347519 | 0.79 | GRM4 (0.46) | GRM5KDM4EALDH1A1 | |
| SCHEMBL3347573 | 0.77 | GRM5 (0.58) | GRM5 | |
| SCHEMBL3351351 | 0.77 | FFAR1 (0.39) | GRM5PDGFRBKDRALDH1A1FFAR1 | |
| SCHEMBL3345830 | 0.77 | FFAR1 (0.40) | GRM5PDGFRBKDRFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |