Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | PTAFR | P25105 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346376 | 0.87 | MC4R (0.63) | MAPTMC4RNPC1GAARAB9A | |
| SCHEMBL3347142 | 0.84 | MC4R (0.59) | MC4RNAMPTKMT2AMEN1NPC1 | |
| SCHEMBL3353041 | 0.81 | CNR1 (0.55) | MAPTMC4RGAAROCK2ALDH1A1 | |
| SCHEMBL3347924 | 0.80 | TAAR1 (0.52) | MAPTMC4RROCK2ALDH1A1CASP1 | |
| SCHEMBL3348201 | 0.80 | CNR1 (0.54) | MAPTMC4RRAB9ASMN1; SMN2ROCK2 | |
| SCHEMBL3346278 | 0.78 | CNR1 (0.57) | MC4RROCK2ALDH1A1SLC6A4 | |
| SCHEMBL3346234 | 0.78 | MC4R (0.71) | MC4RKMT2AGAAROCK2ALDH1A1 | |
| SCHEMBL3410126 | 0.77 | MC4R (0.57) | MC4RNPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL2226816 | 0.77 | MC4R (0.68) | MC4RALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL30585932 | 0.77 | ALDH1A1 (0.52) | MC4RNAMPTHDAC8KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |