Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL1991469 | 0.85 | APOBEC3A (0.51) | APOBEC3AAPOBEC3GJAK2RETKDR | |
| SCHEMBL3347528 | 0.84 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GJAK2RETKDR | |
| SCHEMBL3345963 | 0.83 | APOBEC3A (0.41) | APOBEC3AAPOBEC3G | |
| SCHEMBL3346197 | 0.80 | APOBEC3A (0.37) | APOBEC3AAPOBEC3GLIMK1CLK4MAPK14 | |
| SCHEMBL3348826 | 0.80 | APOBEC3A (0.41) | APOBEC3AAPOBEC3G | |
| Pyridine SCHEMBL3347792 | 0.80 | APOBEC3A (0.46) | APOBEC3AAPOBEC3GCLK4DYRK1AMAPK14 | |
| SCHEMBL3346983 | 0.79 | APOBEC3A (0.40) | APOBEC3AAPOBEC3GKDR | |
| Toluene SCHEMBL9903136 | 0.79 | APOBEC3A (0.43) | APOBEC3AAPOBEC3GJAK2RETKDR | |
| SCHEMBL3346774 | 0.78 | APOBEC3A (0.39) | APOBEC3AAPOBEC3GDYRK1BDYRK1A | |
| Cyclohexene SCHEMBL9903643 | 0.77 | APOBEC3A (0.41) | APOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |