Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 8/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 3/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | PRKACA | P17612 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL1991469 | 0.89 | APOBEC3A (0.51) | APOBEC3AAPOBEC3GKDRPDGFRBPIK3CG | |
| SCHEMBL3346983 | 0.86 | APOBEC3A (0.40) | APOBEC3AAPOBEC3GKDRPDGFRBPIK3CG | |
| Pyridine SCHEMBL3347792 | 0.84 | APOBEC3A (0.46) | APOBEC3AAPOBEC3GMAP4K4PRKACACDK8 | |
| SCHEMBL3347528 | 0.82 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GKDRPDGFRBMAP4K4 | |
| SCHEMBL3346197 | 0.81 | APOBEC3A (0.37) | APOBEC3AAPOBEC3GPIK3CGCDK8CLK4 | |
| SCHEMBL3348826 | 0.81 | APOBEC3A (0.41) | APOBEC3AAPOBEC3G | |
| SCHEMBL3347037 | 0.79 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GKDRMAP4K4PRKACA | |
| SCHEMBL3345963 | 0.78 | APOBEC3A (0.41) | APOBEC3AAPOBEC3G | |
| Cyclohexene SCHEMBL9903643 | 0.78 | APOBEC3A (0.41) | APOBEC3AAPOBEC3G | |
| Toluene SCHEMBL9903320 | 0.78 | MAP4K4 (0.40) | MAP4K4LRRK2CLK4LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178742-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-07-12 | — | — | US | claimed |
| EP-2462142-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-06-13 | — | — | EP | claimed |
| US-20120178742-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-07-12 | — | — | US | disclosed |
| EP-2462142-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178742-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | GRM5, GRIK5, GRM1 | APOBEC3A 4593/4885APOBEC3G 4440/4885KDR 3634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.