Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12299750 | 0.91 | POLB (0.65) | POLBALDH1A1MAPTL3MBTL1TP53 | |
| SCHEMBL14481159 | 0.91 | POLB (0.64) | POLBALDH1A1MAPTL3MBTL1TP53 | |
| SCHEMBL2448301 | 0.90 | POLB (0.59) | POLBALDH1A1MAPTL3MBTL1TP53 | |
| SCHEMBL2442956 | 0.89 | POLB (0.56) | POLBALDH1A1MAPTL3MBTL1TP53 | |
| SCHEMBL2315984 | 0.89 | POLB (0.56) | POLBALDH1A1MAPTL3MBTL1TP53 | |
| SCHEMBL2322198 | 0.89 | POLB (0.56) | POLBALDH1A1MAPTL3MBTL1TP53 | |
| SCHEMBL2323535 | 0.89 | POLB (0.56) | POLBALDH1A1MAPTL3MBTL1TP53 | |
| SCHEMBL2451480 | 0.88 | ALDH1A1 (0.58) | POLBALDH1A1MAPTL3MBTL1TP53 | |
| SCHEMBL2320643 | 0.88 | POLB (0.55) | POLBALDH1A1MAPTL3MBTL1TP53 | |
| SCHEMBL12301082 | 0.88 | POLB (0.55) | POLBALDH1A1MAPTL3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010060532-A1 | BENZONAPHTYRIDINE COMPOUNDS USED AS INHIBITORS OF AUTOTAXIN | MERCK PATENT GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |