Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14481159 | 0.92 | POLB (0.64) | POLBTP53ALDH1A1LMNAKCNT1 | |
| SCHEMBL3348041 | 0.91 | POLB (0.63) | POLBTP53ALDH1A1LMNAKCNT1 | |
| SCHEMBL14481013 | 0.89 | POLB (0.60) | POLBTP53ALDH1A1LMNAKCNT1 | |
| SCHEMBL2421390 | 0.88 | POLB (0.59) | POLBTP53ALDH1A1LMNAKCNT1 | |
| SCHEMBL14480644 | 0.87 | POLB (0.58) | POLBTP53ALDH1A1LMNAKCNT1 | |
| SCHEMBL14480889 | 0.87 | POLB (0.58) | POLBTP53ALDH1A1LMNAKCNT1 | |
| SCHEMBL2448301 | 0.86 | POLB (0.59) | POLBTP53ALDH1A1LMNAKCNT1 | |
| SCHEMBL14481096 | 0.86 | POLB (0.57) | POLBTP53ALDH1A1LMNAKCNT1 | |
| SCHEMBL14551913 | 0.86 | POLB (0.57) | POLBTP53ALDH1A1LMNAKCNT1 | |
| SCHEMBL14480890 | 0.86 | POLB (0.57) | POLBTP53ALDH1A1LMNAKCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552914-B1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2015-11-11 | — | — | EP | disclosed |
| US-9029387-B2 | Benzonaphthyridinamines as autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2015-05-12 | — | — | US | disclosed |
| US-9029387-B2 | Benzonaphthyridinamines as autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2015-05-12 | — | — | US | disclosed |
| US-20130012505-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-01-10 | — | — | US | disclosed |
| US-20130012505-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-01-10 | — | — | US | disclosed |
| WO-2011116867-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012505-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | ENPP2, LYPLAL1, LYPLA1 | POLB 2874/4885TP53 3946/4885ALDH1A1 3057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.