Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 9/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | CDC42 | P60953 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MC5R | P33032 | 2/20 | 0.39 |
| ▸ | MC3R | P41968 | 2/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | MC1R | Q01726 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13364988 | 1.00 | KCNH2 (0.46) | KCNH2MC4RROCK2CDC42PRKCE | |
| SCHEMBL13364989 | 1.00 | KCNH2 (0.46) | KCNH2MC4RROCK2CDC42PRKCE | |
| SCHEMBL3413819 | 0.90 | KCNH2 (0.42) | KCNH2ROCK2 | |
| SCHEMBL3346446 | 0.87 | ROCK2 (0.42) | KCNH2ROCK2CNR1 | |
| SCHEMBL3347822 | 0.84 | KCNH2 (0.45) | KCNH2MC4RROCK2CDC42PRKCE | |
| SCHEMBL3346539 | 0.83 | KCNH2 (0.57) | KCNH2MC4RROCK2CDC42PRKCE | |
| SCHEMBL3346373 | 0.83 | KCNH2 (0.57) | KCNH2MC4RROCK2CDC42PRKCE | |
| SCHEMBL3346204 | 0.82 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL13365045 | 0.82 | MC4R (0.43) | KCNH2MC4RROCK2CDC42PRKCE | |
| SCHEMBL3346905 | 0.80 | KCNH2 (0.49) | KCNH2MC4RROCK2CDC42PRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |