Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13364989 | 0.87 | KCNH2 (0.46) | ROCK2CNR1KCNH2 | |
| SCHEMBL3348197 | 0.87 | KCNH2 (0.46) | ROCK2CNR1KCNH2 | |
| SCHEMBL13364988 | 0.87 | KCNH2 (0.46) | ROCK2CNR1KCNH2 | |
| SCHEMBL3349710 | 0.87 | KCNQ3 (0.46) | KCNH2 | |
| SCHEMBL3346544 | 0.86 | TRPM5 (0.38) | ROCK2MAPK1TRPM5KCNH2 | |
| SCHEMBL3346452 | 0.85 | KCNH2 (0.48) | ROCK2CNR1CNR2MAPK1KCNH2 | |
| SCHEMBL3350848 | 0.84 | ROCK2 (0.41) | ROCK2MAPK1TRPM5KCNH2 | |
| SCHEMBL13365050 | 0.83 | SSTR4 (0.39) | ROCK2CNR2MAPK1KCNH2 | |
| SCHEMBL3413819 | 0.83 | KCNH2 (0.42) | ROCK2CNR2MAPK1KCNH2 | |
| SCHEMBL3350804 | 0.82 | MAPK1 (0.41) | ROCK2MAPK1KCNH2S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |