Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346914 | 0.90 | KCNH2 (0.52) | KCNH2POLBROCK2PRKG1GPR139 | |
| SCHEMBL3346490 | 0.90 | KCNH2 (0.65) | KCNH2POLBROCK2PRKG1MEN1 | |
| SCHEMBL3353031 | 0.88 | KCNH2 (0.59) | KCNH2ROCK2GPR139 | |
| SCHEMBL3347178 | 0.87 | KCNH2 (0.53) | KCNH2POLBROCK2PRKG1MEN1 | |
| SCHEMBL3348185 | 0.87 | POLB (0.53) | KCNH2POLBROCK2PRKG1MEN1 | |
| SCHEMBL3346274 | 0.87 | POLB (0.54) | KCNH2POLBROCK2PRKG1MEN1 | |
| SCHEMBL3346506 | 0.84 | KCNH2 (0.51) | KCNH2POLBROCK2PRKG1MEN1 | |
| SCHEMBL3353232 | 0.83 | POLB (0.53) | KCNH2POLBROCK2PRKG1MEN1 | |
| SCHEMBL3347954 | 0.83 | POLB (0.54) | KCNH2POLBROCK2PRKG1MEN1 | |
| SCHEMBL3412005 | 0.82 | KCNH2 (0.55) | KCNH2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |