Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.38 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | MC5R | P33032 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348200 | 0.90 | KCNH2 (0.52) | KCNH2ROCK2GPR139POLBPRKG1 | |
| SCHEMBL3353031 | 0.89 | KCNH2 (0.59) | KCNH2ROCK2PDE2AGPR139KCNQ3 | |
| SCHEMBL3350659 | 0.87 | KCNH2 (0.68) | KCNH2OPRM1ROCK2PDE2AKCNQ3 | |
| SCHEMBL13365111 | 0.87 | KCNH2 (0.68) | KCNH2OPRM1ROCK2PDE2AKCNQ3 | |
| SCHEMBL13365065 | 0.85 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353036 | 0.85 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL13365099 | 0.85 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353124 | 0.85 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353040 | 0.82 | KCNH2 (0.48) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3347928 | 0.81 | KCNH2 (0.53) | KCNH2ROCK2KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |