Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.64 |
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346995 | 0.86 | GRM5 (0.56) | KDRPDGFRBGRM5IKBKBKDM4E | |
| SCHEMBL17409474 | 0.78 | KDR (1.00) | KDRPDGFRBKIT | |
| SCHEMBL3347519 | 0.77 | GRM4 (0.46) | GRM5KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL17424247 | 0.76 | KDR (0.80) | KDRPDGFRBGRM5KCNK3KCNK9 | |
| SCHEMBL3346980 | 0.73 | GRM5 (0.49) | KDRPDGFRBGRM5KDM4ELMNA | |
| SCHEMBL3347295 | 0.73 | GRM5 (0.48) | GRM5 | |
| SCHEMBL3346805 | 0.73 | DYRK1A (0.43) | GRM5RAB9A | |
| SCHEMBL2416002 | 0.73 | KCNK3 (0.59) | KDRPDGFRBKCNK3KCNK9POLB | |
| SCHEMBL3348434 | 0.73 | GRM5 (0.54) | GRM5 | |
| SCHEMBL3347261 | 0.73 | GRM5 (0.47) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |