Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347287 | 0.80 | DYRK1A (0.44) | GRM5DYRK1ASCN5APIM1PIM3 | |
| SCHEMBL3347789 | 0.77 | GRM5 (0.49) | GRM5DYRK1AOGASCN5ATGFBR1 | |
| SCHEMBL3346563 | 0.76 | CYP2A6 (0.45) | DYRK1AOGASCN5AFFAR1TGFBR1 | |
| SCHEMBL3347609 | 0.76 | GRM5 (0.33) | GRM5DYRK1A | |
| SCHEMBL3346767 | 0.75 | GRM5 (0.46) | GRM5DYRK1AOGASCN5A | |
| SCHEMBL3347519 | 0.75 | GRM4 (0.46) | GRM5DYRK1A | |
| SCHEMBL3348444 | 0.75 | CHRM2 (0.35) | GRM5DYRK1ASCN5A | |
| SCHEMBL3347027 | 0.74 | GRM5 (0.50) | GRM5DYRK1ATGFBR1 | |
| SCHEMBL3346766 | 0.73 | GRM5 (0.53) | GRM5TGFBR1 | |
| SCHEMBL3346384 | 0.72 | GRM5 (0.43) | GRM5DYRK1AOGATGFBR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |