Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | OGA | O60502 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347616 | 0.79 | DYRK1A (0.40) | CYP2A6OGADYRK1AALDH1A1HPGD | |
| SCHEMBL3347593 | 0.78 | OGA (0.42) | OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL3347052 | 0.78 | CYP2A6 (0.37) | CYP2A6OGADYRK1AALDH1A1HPGD | |
| SCHEMBL3347020 | 0.77 | CYP2A6 (0.36) | CYP2A6OGAALDH1A1HPGDTGFBR1 | |
| SCHEMBL3348818 | 0.76 | GRM5 (0.47) | OGADYRK1ATGFBR1FFAR1SCN5A | |
| SCHEMBL3346192 | 0.76 | GRM5 (0.47) | OGADYRK1ATGFBR1SCN5A | |
| SCHEMBL3346766 | 0.76 | GRM5 (0.53) | ALDH1A1HPGDTGFBR1KDM4ECYP1A2 | |
| SCHEMBL3346384 | 0.74 | GRM5 (0.43) | OGADYRK1AALDH1A1HPGDTGFBR1 | |
| SCHEMBL3346767 | 0.72 | GRM5 (0.46) | CYP2A6OGADYRK1ASCN5A | |
| SCHEMBL3351201 | 0.72 | OGA (0.37) | OGADYRK1ATGFBR1SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |