Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347519 | 0.80 | GRM4 (0.46) | GRM5DYRK1ANPC1RAB9AMEN1 | |
| SCHEMBL3347789 | 0.79 | GRM5 (0.49) | GRM5DYRK1AOGANPC1RAB9A | |
| SCHEMBL3346476 | 0.78 | DYRK1A (0.41) | GRM5CYP2A6DYRK1ATDP1L3MBTL1 | |
| SCHEMBL3347283 | 0.77 | CYP2A6 (0.36) | GRM5CYP2A6DYRK1A | |
| SCHEMBL3351686 | 0.77 | GRM5 (0.49) | GRM5DYRK1AOGASCN5A | |
| SCHEMBL3346384 | 0.77 | GRM5 (0.43) | GRM5DYRK1AOGANPC1RAB9A | |
| SCHEMBL3346603 | 0.77 | GRM5 (0.41) | GRM5DYRK1AOGANPC1RAB9A | |
| SCHEMBL3346523 | 0.76 | CYP2A6 (0.35) | GRM5CYP2A6DYRK1ASCN5A | |
| SCHEMBL3348818 | 0.75 | GRM5 (0.47) | GRM5DYRK1AOGASCN5A | |
| SCHEMBL3345958 | 0.75 | GRM5 (0.52) | GRM5CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |