Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | GSR | P00390 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11827286 | 0.82 | MAPT (0.59) | MAOBMEN1KMT2ACA12AKR1B10 | |
| SCHEMBL28642609 | 0.82 | CA12 (0.53) | MAOBCA12AKR1B10CA1CA2 | |
| SCHEMBL21954717 | 0.82 | CA12 (0.53) | MAOBCA12AKR1B10CA1CA2 | |
| SCHEMBL11827282 | 0.82 | MAPT (0.59) | MAOBMEN1KMT2ACA12AKR1B10 | |
| SCHEMBL5707175 | 0.81 | MAOB (0.69) | MAOBHDAC1HDAC8HDAC6GSR | |
| SCHEMBL2152899 | 0.81 | MAOB (0.69) | MAOBHDAC1HDAC8HDAC6GSR | |
| SCHEMBL2152903 | 0.81 | MAOB (0.69) | MAOBHDAC1HDAC8HDAC6GSR | |
| SCHEMBL336240 | 0.81 | MMP1 (0.52) | MAOBMEN1KMT2ACA12AKR1B10 | |
| SCHEMBL336239 | 0.81 | MMP1 (0.52) | MAOBMEN1KMT2ACA12AKR1B10 | |
| SCHEMBL15836 | 0.79 | NFE2L2 (0.66) | MAOBMEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069289-B1 | ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXa INHIBITORS | SANOFI SA (FR) | 2013-10-02 | — | — | EP | disclosed |
| CN-101516834-B | Isoserine derivatives for use as coagulation factor IXa inhibitors | SANOFI AVENTIS | 2013-04-03 | — | — | CN | disclosed |
| US-8097758-B2 | Isoserine derivatives for use as coagulation factor IXa inhibitors | SANOFI-AVENTIS (FR) | 2012-01-17 | — | — | US | disclosed |
| CN-101516834-A | Isoserine derivatives for use as coagulation factor ixa inhibitors | SANOFI AVENTIS (FR) | 2009-08-26 | — | — | CN | disclosed |
| EP-2069289-A1 | ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXa INHIBITORS | Sanofi-Aventis (FR) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008031509-A1 | ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXa INHIBITORS | SANOFI-AVENTIS (FR) | 2008-03-20 | — | — | WO | disclosed |