Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381358 | 0.90 | NR1H2 (0.35) | EGFRNR1H2NR1H3SMN1; SMN2 | |
| SCHEMBL3350743 | 0.85 | NR1H2 (0.46) | EGFRNR1H2NR1H3KDRSMN1; SMN2 | |
| SCHEMBL3348163 | 0.81 | EGFR (0.38) | EGFRNR1H2NR1H3KDR | |
| SCHEMBL2446897 | 0.80 | FGFR2 (0.41) | EGFRKDRKCNH2 | |
| SCHEMBL3509660 | 0.77 | MAP4K4 (0.39) | EGFRNR1H2NR1H3 | |
| SCHEMBL3510252 | 0.76 | KMO (0.49) | NR1H2NR1H3 | |
| SCHEMBL3507434 | 0.76 | NR1H2 (0.58) | NR1H2NR1H3 | |
| SCHEMBL2446322 | 0.76 | NR1H3 (0.46) | EGFRNR1H2NR1H3 | |
| SCHEMBL27775786 | 0.75 | KMT2A (0.40) | EGFRSMN1; SMN2 | |
| SCHEMBL3506200 | 0.74 | NR1H2 (0.55) | NR1H2NR1H3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059627-A1 | POLAR QUINAZOLINES AS LIVER X RECEPTORS ( LXRS ) MODULATORS | WYETH LLC (US) | 2010-05-27 | — | — | WO | disclosed |