SCHEMBL3351175

SCHEMBL3351175

C[C@@H](NC(=O)c1cccc(C(N)=O)c1)c1ccccc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.69
LMNA P02545 2/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
NPC1 O15118 1/20 0.57
GPR139 Q6DWJ6 4/20 0.55
MAPK1 P28482 2/20 0.54
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
GAA P10253 1/20 0.54
PKM P14618 1/20 0.54
KDM4E B2RXH2 1/20 0.54
HDAC3 O15379 1/20 0.52
HDAC4 P56524 1/20 0.52
HDAC1 Q13547 1/20 0.52
ROCK2 O75116 1/20 0.52
RPS6KA5 O75582 1/20 0.52
MAP4K4 O95819 1/20 0.52
CDK1 P06493 1/20 0.52
CSF1R P07333 1/20 0.52
PRKACA P17612 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3345042 1.00 ALDH1A1 (0.69) ALDH1A1LMNASMN1; SMN2NPC1GPR139
SCHEMBL3646228 1.00 ALDH1A1 (0.69) ALDH1A1LMNASMN1; SMN2NPC1GPR139
SCHEMBL3686677 0.91 ALDH1A1 (0.60) ALDH1A1LMNASMN1; SMN2NPC1MAPK1
SCHEMBL3640686 0.88 ALDH1A1 (0.55) ALDH1A1LMNASMN1; SMN2GPR139MAPK1
SCHEMBL13229107 0.88 ALDH1A1 (0.73) ALDH1A1LMNASMN1; SMN2NPC1GPR139
SCHEMBL30358447 0.86 ALDH1A1 (0.71) ALDH1A1LMNASMN1; SMN2NPC1GPR139
SCHEMBL10777991 0.85 ALDH1A1 (0.69) ALDH1A1LMNASMN1; SMN2NPC1GPR139
SCHEMBL3508505 0.85 ALDH1A1 (0.69) ALDH1A1LMNASMN1; SMN2NPC1GPR139
SCHEMBL8659273 0.84 ALDH1A1 (0.49) ALDH1A1LMNAGAAPOLBTDP1
SCHEMBL13229106 0.84 ALDH1A1 (0.68) ALDH1A1LMNASMN1; SMN2NPC1GPR139

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2178837-A2 ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY COMENTIS, INC. (US) 2010-04-28 EP claimed
WO-2009015369-A2 COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2009-01-29 WO claimed
EP-2178837-A2 ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY COMENTIS, INC. (US) 2010-04-28 EP disclosed
WO-2010042030-A1 ASPARTYL PROTEASE INHIBITORS MEDIVIR AB (SE) 2010-04-15 WO disclosed
WO-2009015369-A2 COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2009-01-29 WO disclosed