Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.59 |
| ▸ | KDR | P35968 | 9/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | USP7 | Q93009 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24238656 | 0.85 | PDGFRB (0.77) | MAP4K4PDGFRBKDRFYNCHEK2 | |
| SCHEMBL29994102 | 0.82 | PDGFRB (0.61) | PDGFRBKDRFYNGABRA5CHEK2 | |
| SCHEMBL21994688 | 0.82 | PDGFRB (0.61) | PDGFRBKDRFYNGABRA5CHEK2 | |
| SCHEMBL2222523 | 0.81 | GABRA5 (0.52) | GABRA5SLC6A3SLC6A2 | |
| SCHEMBL17668204 | 0.80 | PDGFRB (0.69) | MAP4K4PDGFRBKDRFYNCHEK2 | |
| SCHEMBL4533112 | 0.78 | MAPK14 (0.48) | MAP4K4FYNMAPK14SLC6A3SLC6A2 | |
| SCHEMBL3460106 | 0.77 | ATR (0.67) | — | |
| SCHEMBL4531010 | 0.77 | RORC (0.49) | FYNMAPK14SLC6A3SLC6A2 | |
| SCHEMBL14889591 | 0.76 | ATR (0.46) | MAP4K4FYNDHFRGABRA5SLC6A3 | |
| SCHEMBL4592371 | 0.76 | CYP11B1 (0.58) | KDRGABRA5SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |