Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | MAX | P61244 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767362 | 0.94 | VCAM1 (0.49) | VCAM1ALDH1A1HPGDNPSR1AR | |
| SCHEMBL2484778 | 0.93 | VCAM1 (0.57) | VCAM1ALDH1A1HPGDNPSR1PKM | |
| SCHEMBL8768519 | 0.90 | VCAM1 (0.46) | VCAM1ALDH1A1HPGDNPSR1AR | |
| SCHEMBL3354100 | 0.87 | KMT2A (0.53) | ALDH1A1PKMPOLBMAPTGAA | |
| SCHEMBL7031271 | 0.84 | VCAM1 (0.63) | VCAM1ALDH1A1HPGDNPSR1AR | |
| SCHEMBL31336381 | 0.83 | MAPT (0.57) | ALDH1A1HPGDNPSR1PKMNOTUM | |
| SCHEMBL4580602 | 0.83 | MAPT (0.57) | ALDH1A1HPGDNPSR1PKMNOTUM | |
| SCHEMBL2934710 | 0.83 | MAPT (0.57) | ALDH1A1NPSR1PKMNOTUMMAPT | |
| SCHEMBL31238876 | 0.83 | MAPT (0.57) | ALDH1A1NPSR1PKMNOTUMMAPT | |
| SCHEMBL2315350 | 0.82 | LCK (0.43) | VCAM1ALDH1A1HPGDNPSR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9918959-B2 | TLR-independent small molecule adjuvants | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-03-20 | — | — | US | disclosed |
| US-20170224653-A1 | TLR-INDEPENDENT SMALL MOLECULE ADJUVANTS | THE SCRIPPS RESEARCH INSTITUTE | 2017-08-10 | — | — | US | disclosed |
| US-20170224653-A1 | TLR-INDEPENDENT SMALL MOLECULE ADJUVANTS | THE SCRIPPS RESEARCH INSTITUTE | 2017-08-10 | — | — | US | disclosed |
| US-9649373-B2 | Neoseptins: small molecule adjuvants | THE SCRIPPS INSTITUTE (US) | 2017-05-16 | — | — | US | disclosed |
| US-9649373-B2 | Neoseptins: small molecule adjuvants | THE SCRIPPS INSTITUTE (US) | 2017-05-16 | — | — | US | disclosed |
| EP-2958889-B1 | NEOSEPTINS: SMALL MOLECULE ADJUVANTS | SCRIPPS RESEARCH INST (US) | 2017-03-22 | — | — | EP | disclosed |
| WO-2016022700-A2 | TLR-INDEPENDENT SMALL MOLECULE ADJUVANTS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-02-11 | — | — | WO | disclosed |
| US-20160000907-A1 | NEOSEPTINS: SMALL MOLECULE ADJUVANTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-01-07 | — | — | US | disclosed |
| US-20160000907-A1 | NEOSEPTINS: SMALL MOLECULE ADJUVANTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-01-07 | — | — | US | disclosed |
| WO-2014131023-A1 | NEOSEPTINS: SMALL MOLECULE ADJUVANTS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-08-28 | — | — | WO | disclosed |
| US-7727997-B2 | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7727997-B2 | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070213316-A1 | Compounds that are effective inhibitors of beta-secretase; inhibitors of beta-secretase-mediated cleavage of amyloid precursor proteins; effective inhibitors of A beta production, and/or are effective to reduce amyloid beta deposits or plaques; treatment of disorders such as Alzheimer's Disease | ELAN PHARMACEUTICALS, INC. | 2007-09-13 | — | — | US | disclosed |
| US-20070213316-A1 | Compounds that are effective inhibitors of beta-secretase; inhibitors of beta-secretase-mediated cleavage of amyloid precursor proteins; effective inhibitors of A beta production, and/or are effective to reduce amyloid beta deposits or plaques; treatment of disorders such as Alzheimer's Disease | ELAN PHARMACEUTICALS, INC. | 2007-09-13 | — | — | US | disclosed |
| US-7176242-B2 | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176242-B2 | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-02-13 | — | — | US | disclosed |
| WO-2006012310-A2 | CARBAZOLE DERIVATIVES FOR TREATING POLYCYSTIC KIDNEY DISEASE | GENZYME CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |
| US-20040171881-A1 | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives | PHARMACIA & UPJOHN COMPANY | 2004-09-02 | — | — | US | disclosed |
| US-5872280-A | RESPIRATORY SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171881-A1 | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives | BACE1, BACE2, PSEN1 | VCAM1 3842/4885ALDH1A1 527/4885HPGD 155/4885 |
| US-20160000907-A1 | NEOSEPTINS: SMALL MOLECULE ADJUVANTS | TLR2, TLR4, TLR1 | VCAM1 2113/4885ALDH1A1 4691/4885HPGD 623/4885 |
| US-20070213316-A1 | Compounds that are effective inhibitors of beta-secretase; inhibitors of beta-secretase-mediated cleavage of amyloid precursor proteins; effective inhibitors of A beta production, and/or are effective to reduce amyloid beta deposits or plaques; treatment of disorders such as Alzheimer's Disease | BACE1, BACE2, APP | VCAM1 3540/4885ALDH1A1 2133/4885HPGD 1390/4885 |
| US-20170224653-A1 | TLR-INDEPENDENT SMALL MOLECULE ADJUVANTS | TLR1, TLR9, TLR3 | VCAM1 2755/4885ALDH1A1 4837/4885HPGD 3221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.