Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.40 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13365065 | 0.90 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353036 | 0.90 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL13365099 | 0.90 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353124 | 0.90 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3346605 | 0.89 | KCNH2 (0.55) | KCNH2ROCK2SLC6A2KCNQ3KCNQ2 | |
| SCHEMBL13365126 | 0.89 | KCNH2 (0.52) | KCNH2ROCK2SLC6A2KCNQ3KCNQ2 | |
| SCHEMBL3353133 | 0.88 | KCNH2 (0.47) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353232 | 0.86 | POLB (0.53) | KCNH2ROCK2SLC6A2LMNAHTT | |
| SCHEMBL3353108 | 0.85 | KCNH2 (0.46) | KCNH2ROCK2KCNQ3KCNQ2 | |
| SCHEMBL13365111 | 0.84 | KCNH2 (0.68) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |