Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MC4R | P32245 | 5/20 | 0.43 |
| ▸ | MC5R | P33032 | 2/20 | 0.43 |
| ▸ | MC3R | P41968 | 2/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.42 |
| ▸ | CDC42 | P60953 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.41 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.41 |
| ▸ | MC1R | Q01726 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13365099 | 1.00 | KCNH2 (0.52) | KCNH2MC4RMC5RMC3RKCNQ3 | |
| SCHEMBL13365065 | 1.00 | KCNH2 (0.52) | KCNH2MC4RMC5RMC3RKCNQ3 | |
| SCHEMBL3353036 | 1.00 | KCNH2 (0.52) | KCNH2MC4RMC5RMC3RKCNQ3 | |
| SCHEMBL3353133 | 0.92 | KCNH2 (0.47) | KCNH2MC4RMC5RMC3RKCNQ3 | |
| SCHEMBL3353040 | 0.90 | KCNH2 (0.48) | KCNH2KCNQ3KCNQ2ROCK2SLC6A4 | |
| SCHEMBL3346492 | 0.88 | ROCK2 (0.46) | KCNH2MC4RKCNQ3KCNQ2ROCK2 | |
| SCHEMBL13365111 | 0.88 | KCNH2 (0.68) | KCNH2MC4RKCNQ3KCNQ2ROCK2 | |
| SCHEMBL3350659 | 0.88 | KCNH2 (0.68) | KCNH2MC4RKCNQ3KCNQ2ROCK2 | |
| SCHEMBL3353108 | 0.87 | KCNH2 (0.46) | KCNH2KCNQ3KCNQ2ROCK2 | |
| SCHEMBL13364977 | 0.87 | KCNH2 (0.60) | KCNH2MC4RMC5RMC3RKCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |