Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.39 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353036 | 0.92 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2SLC6A4 | |
| SCHEMBL13365099 | 0.92 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2SLC6A4 | |
| SCHEMBL13365065 | 0.92 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2SLC6A4 | |
| SCHEMBL3353124 | 0.92 | KCNH2 (0.52) | KCNH2ROCK2KCNQ3KCNQ2SLC6A4 | |
| SCHEMBL13365101 | 0.88 | KCNH2 (0.54) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353138 | 0.88 | KCNQ3 (0.52) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353040 | 0.88 | KCNH2 (0.48) | KCNH2ROCK2KCNQ3KCNQ2SLC6A4 | |
| SCHEMBL3347954 | 0.86 | POLB (0.54) | KCNH2ROCK2POLBMAPK1PRKG1 | |
| SCHEMBL3346492 | 0.86 | ROCK2 (0.46) | KCNH2ROCK2KCNQ3KCNQ2SLC6A4 | |
| SCHEMBL3353108 | 0.85 | KCNH2 (0.46) | KCNH2ROCK2KCNQ3KCNQ2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |