Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | TLR2 | O60603 | 3/20 | 0.46 |
| ▸ | TLR1 | Q15399 | 3/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410126 | 0.89 | MC4R (0.57) | TAAR1KCNH2TLR2TLR1MC4R | |
| SCHEMBL3353112 | 0.88 | MC4R (0.43) | TAAR1KCNH2MC4RROCK2POLB | |
| SCHEMBL3347924 | 0.86 | TAAR1 (0.52) | TAAR1KCNH2TLR2TLR1MC4R | |
| SCHEMBL3415193 | 0.86 | KCNH2 (0.65) | TAAR1KCNH2TLR2TLR1MC4R | |
| SCHEMBL3348171 | 0.84 | TAAR1 (0.53) | TAAR1KCNH2MC4RPOLBNPC1 | |
| SCHEMBL3346608 | 0.83 | KCNH2 (0.50) | TAAR1KCNH2TLR2TLR1MC4R | |
| SCHEMBL3410485 | 0.82 | MC4R (0.43) | TAAR1KCNH2MC4RROCK2POLB | |
| SCHEMBL3350885 | 0.81 | TAAR1 (0.47) | TAAR1TLR2TLR1MC4RPOLB | |
| SCHEMBL3352433 | 0.80 | CNR1 (0.46) | KCNH2MC4RROCK2RAB9AMEN1 | |
| SCHEMBL22622421 | 0.79 | TAAR1 (0.66) | TAAR1TLR2TLR1MC4RPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |