Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 12/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 12/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 12/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251823 | 0.86 | ADRA2A (0.75) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL3353162 | 0.79 | ADRA2A (0.71) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL3346716 | 0.79 | ADRA2A (0.63) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7031798 | 0.71 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL253111 | 0.67 | ADRA2A (0.82) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7028091 | 0.66 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7032974 | 0.66 | ADRA2A (0.73) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL3346324 | 0.66 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL11248384 | 0.65 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL12208914 | 0.65 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012001065-A2 | METHOD FOR PREVENTING OR TREATING SKIN TUMOR | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-05 | — | — | WO | disclosed |
| WO-2011061252-A2 | COMBINATION THERAPY FOR TREATING OR PREVENTING AN INFLAMMATORY SKIN DISORDER | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-05-26 | — | — | WO | disclosed |