Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3354603 | 0.89 | FLT3 (0.40) | FLT3MAPKAPK2NR3C1LMNA | |
| SCHEMBL3356274 | 0.78 | BCL2A1 (0.40) | MAPKAPK2TP53MAPT | |
| SCHEMBL509034 | 0.73 | LCK (0.43) | OGAEGFRTP53MAPT | |
| SCHEMBL509035 | 0.73 | LCK (0.43) | OGAEGFRTP53MAPT | |
| SCHEMBL508873 | 0.64 | MAPK14 (0.46) | EGFRMAPTLMNA | |
| SCHEMBL508872 | 0.64 | MAPK14 (0.46) | EGFRMAPTLMNA | |
| SCHEMBL509174 | 0.62 | LCK (0.46) | OGATP53MAPTLMNA | |
| SCHEMBL509175 | 0.62 | LCK (0.46) | OGATP53MAPTLMNA | |
| SCHEMBL10188155 | 0.62 | MCHR1 (0.43) | EGFRMAPTLMNACHRM1HTR2A | |
| SCHEMBL5169399 | 0.61 | SLC6A2 (0.41) | EGFRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054107-A2 | KINASE KNOCKDOWN VIA ELECTROPHILICALLY ENHANCED INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2010-05-14 | — | — | WO | disclosed |