Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2A1 | Q16548 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353914 | 0.78 | FLT3 (0.38) | TP53MAPTMAPKAPK2 | |
| SCHEMBL508540 | 0.78 | ACHE (0.41) | BCL2A1SMN1; SMN2TP53MAPTGAA | |
| SCHEMBL508541 | 0.78 | ACHE (0.41) | BCL2A1SMN1; SMN2TP53MAPTGAA | |
| SCHEMBL508843 | 0.76 | MAPK13 (0.40) | BCL2A1SMN1; SMN2TP53MAPTGAA | |
| SCHEMBL508844 | 0.76 | MAPK13 (0.40) | BCL2A1SMN1; SMN2TP53MAPTGAA | |
| SCHEMBL508477 | 0.74 | BCL2A1 (0.45) | BCL2A1SMN1; SMN2TP53MAPTMAPKAPK2 | |
| SCHEMBL509223 | 0.70 | BCL2A1 (0.56) | BCL2A1SMN1; SMN2TP53MAPTGAA | |
| SCHEMBL3359043 | 0.68 | ACHE (0.44) | BCL2A1SMN1; SMN2TP53MAPTGAA | |
| SCHEMBL3354603 | 0.68 | FLT3 (0.40) | SMN1; SMN2MAPKAPK2KMT2A | |
| SCHEMBL508263 | 0.65 | ALDH1A1 (0.49) | BCL2A1TP53MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054107-A2 | KINASE KNOCKDOWN VIA ELECTROPHILICALLY ENHANCED INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2010-05-14 | — | — | WO | disclosed |