Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 11/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | THRB | P10828 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | HTR1B | P28222 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146560 | 0.91 | ADRA2A (0.66) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C | |
| SCHEMBL9475202 | 0.89 | ADRA2A (0.62) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C | |
| Rauwolscine SCHEMBL564078 | 0.80 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C | |
| Rauwolscine SCHEMBL22703462 | 0.80 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C | |
| Rauwolscine SCHEMBL13932206 | 0.80 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C | |
| Rauwolscine SCHEMBL25366080 | 0.80 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C | |
| Rauwolscine SCHEMBL10020758 | 0.80 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C | |
| Rauwolscine SCHEMBL23244673 | 0.80 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C | |
| Yohimbine SCHEMBL33954 | 0.80 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C | |
| Rauwolscine SCHEMBL8097702 | 0.80 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-08-21 | — | — | US | disclosed |
| US-8748177-B2 | Compositions for proliferation of cells and related methods | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-06-10 | — | — | US | disclosed |
| US-20110301105-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2011-12-08 | — | — | US | disclosed |
| WO-2010039679-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | MKI67, KRT18, PROX1 | ADRA2A 4834/4885ADRA1A 4760/4885CYP2D6 4157/4885 |
| US-20110301105-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | MKI67, KRT18, PROX1 | ADRA2A 4834/4885ADRA1A 4760/4885CYP2D6 4157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.