Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NSD2 | O96028 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15910937 | 0.85 | KDM4E (0.51) | KDM4EMAPTALDH1A1NSD2IRAK4 | |
| SCHEMBL3353393 | 0.85 | ALDH1A1 (0.47) | KDM4EMAPTALDH1A1NSD2IRAK4 | |
| SCHEMBL3351305 | 0.85 | MAPT (0.47) | KDM4EMAPTALDH1A1NSD2IRAK4 | |
| SCHEMBL25912147 | 0.83 | TLR8 (0.41) | IRAK4TLR8AXLGAASMN1; SMN2 | |
| SCHEMBL26684343 | 0.81 | KDM4E (0.42) | KDM4EMAPTALDH1A1NSD2IRAK4 | |
| SCHEMBL13537512 | 0.80 | TLR8 (0.42) | IRAK4TLR8AXLGAASMN1; SMN2 | |
| SCHEMBL3358873 | 0.78 | MAPT (0.59) | MAPTALDH1A1IRAK4TLR8SMN1; SMN2 | |
| SCHEMBL25338952 | 0.77 | NR1H2 (0.46) | KDM4EMAPTALDH1A1IRAK4HTT | |
| SCHEMBL26683618 | 0.75 | CRBN (0.41) | IRAK4TLR8AXL | |
| SCHEMBL29081357 | 0.75 | TLR8 (0.36) | IRAK4TLR8AXLGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |