Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3352325 | 1.00 | JAK2 (0.52) | JAK2JAK1HTR2AHSD11B1GPR119 | |
| SCHEMBL30368581 | 0.88 | SIGMAR1 (0.52) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL2850358 | 0.88 | JAK2 (0.52) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL2850359 | 0.88 | JAK2 (0.52) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL3355641 | 0.87 | HTR2A (0.54) | HTR2A | |
| SCHEMBL2844701 | 0.86 | JAK2 (0.48) | JAK2JAK1HTR2AHSD11B1GPR119 | |
| SCHEMBL2844705 | 0.86 | JAK2 (0.48) | JAK2JAK1HTR2AHSD11B1GPR119 | |
| SCHEMBL2849224 | 0.84 | JAK2 (0.49) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL2849228 | 0.84 | JAK2 (0.49) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL3805677 | 0.83 | JAK2 (0.47) | JAK2JAK1HSD11B1GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144717-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE-DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144717-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE-DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | NQO2, SDHA, NDUFS5 | JAK2 2220/4885JAK1 2981/4885HTR2A 1487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.