Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL324193 | 0.99 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2NPSR1NPY5RSCN9A | |
| SCHEMBL15940580 | 0.70 | CASP1 (0.64) | ALDH1A1NPSR1NPY5RSCN9AKDM4E | |
| SCHEMBL3356245 | 0.65 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2NPSR1NPY5RSCN9A | |
| SCHEMBL17227738 | 0.65 | ERCC1 (0.46) | ALDH1A1SMN1; SMN2NPSR1NPY5RCDC7 | |
| SCHEMBL28144523 | 0.64 | SCN9A (0.51) | ALDH1A1SCN9AKDM4ECHEK2MAPK1 | |
| Hydrochloric Acid SCHEMBL324192 | 0.64 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2NPSR1NPY5RSCN9A | |
| SCHEMBL17942866 | 0.64 | HTT (0.50) | ALDH1A1NPSR1NPY5RSCN9AKDM4E | |
| SCHEMBL4843377 | 0.64 | — | — | |
| SCHEMBL3451175 | 0.63 | HPGD (0.56) | ALDH1A1SMN1; SMN2NPSR1SCN9AKDM4E | |
| SCHEMBL3356250 | 0.63 | IDH2 (0.41) | ALDH1A1SMN1; SMN2NPSR1KDM4ECDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120801-A1 | AKT AND P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY | 2010-05-13 | — | — | US | disclosed |
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120801-A1 | AKT AND P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, MTOR | ALDH1A1 4352/4885SMN1; SMN2 3551/4885NPSR1 2813/4885 |
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, RPS6KA2 | ALDH1A1 4473/4885SMN1; SMN2 1352/4885NPSR1 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.