Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 17/20 | 0.42 |
| ▸ | BTK | Q06187 | 5/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358663 | 0.88 | ZAP70 (0.57) | ZAP70SYKJAK2 | |
| SCHEMBL3359423 | 0.87 | ZAP70 (0.55) | ZAP70SYKJAK2 | |
| SCHEMBL3359065 | 0.87 | ZAP70 (0.55) | ZAP70SYKJAK2 | |
| SCHEMBL3359539 | 0.87 | ZAP70 (0.65) | ZAP70SYKJAK2 | |
| SCHEMBL3362594 | 0.86 | ZAP70 (0.55) | ZAP70SYKJAK2PIK3CA | |
| SCHEMBL3359176 | 0.85 | ZAP70 (0.54) | ZAP70SYKJAK2PIK3CA | |
| SCHEMBL3362713 | 0.84 | ZAP70 (0.56) | ZAP70SYKJAK2PIK3CA | |
| SCHEMBL3357730 | 0.83 | ZAP70 (0.55) | ZAP70SYKJAK2 | |
| SCHEMBL3359939 | 0.83 | ZAP70 (0.55) | ZAP70SYKJAK2 | |
| SCHEMBL3360938 | 0.83 | ZAP70 (0.49) | ZAP70JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |