Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.56 |
| ▸ | SYK | P43405 | 5/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3357730 | 0.93 | ZAP70 (0.55) | ZAP70SYKTNK2SMOP2RX3 | |
| SCHEMBL3359939 | 0.93 | ZAP70 (0.55) | ZAP70SYKTNK2SMOP2RX3 | |
| SCHEMBL3359539 | 0.93 | ZAP70 (0.65) | ZAP70SYKTNK2SMOJAK2 | |
| SCHEMBL3362516 | 0.92 | ZAP70 (0.47) | ZAP70SYKSMOP2RX3PIK3CG | |
| SCHEMBL3359176 | 0.92 | ZAP70 (0.54) | ZAP70SYKTNK2SMOPIK3CG | |
| SCHEMBL3358663 | 0.90 | ZAP70 (0.57) | ZAP70SYKTNK2SMOJAK2 | |
| SCHEMBL3359423 | 0.90 | ZAP70 (0.55) | ZAP70SYKTNK2SMOJAK2 | |
| SCHEMBL3359065 | 0.90 | ZAP70 (0.55) | ZAP70SYKTNK2SMOJAK2 | |
| SCHEMBL3362594 | 0.89 | ZAP70 (0.55) | ZAP70SYKTNK2SMOPIK3CA | |
| SCHEMBL3357809 | 0.88 | SYK (0.44) | ZAP70SYKSMOPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |