Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 5/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 8/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359539 | 0.93 | ZAP70 (0.65) | ZAP70SYKTNK2JAK2JAK1 | |
| SCHEMBL3362594 | 0.93 | ZAP70 (0.55) | ZAP70SYKTNK2JAK2JAK1 | |
| SCHEMBL3362937 | 0.93 | ZAP70 (0.48) | ZAP70SYKJAK2JAK1TYK2 | |
| SCHEMBL3359176 | 0.91 | ZAP70 (0.54) | ZAP70SYKTNK2JAK2JAK1 | |
| SCHEMBL3362713 | 0.90 | ZAP70 (0.56) | ZAP70SYKTNK2JAK2JAK1 | |
| SCHEMBL3359423 | 0.90 | ZAP70 (0.55) | ZAP70SYKTNK2JAK2JAK1 | |
| SCHEMBL3359065 | 0.90 | ZAP70 (0.55) | ZAP70SYKTNK2JAK2JAK1 | |
| SCHEMBL3359939 | 0.89 | ZAP70 (0.55) | ZAP70SYKTNK2JAK2JAK1 | |
| SCHEMBL3357730 | 0.89 | ZAP70 (0.55) | ZAP70SYKTNK2JAK2JAK1 | |
| SCHEMBL3356729 | 0.88 | ZAP70 (0.53) | ZAP70SYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |