Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 6/20 | 0.82 |
| ▸ | FDPS | P14324 | 7/20 | 0.69 |
| ▸ | PTPN5 | P54829 | 6/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13431339 | 0.90 | GGPS1 (1.00) | GGPS1FDPSPTPN5PTPN1BTN3A1 | |
| SCHEMBL3356307 | 0.85 | FDPS (0.71) | GGPS1FDPSPTPN5BTN3A1PDE3A | |
| SCHEMBL3846830 | 0.82 | FDPS (1.00) | GGPS1FDPSBTN3A1PDE3A | |
| SCHEMBL30951466 | 0.79 | GGPS1 (0.56) | GGPS1FDPSPTPN5PTPN1 | |
| SCHEMBL13458845 | 0.78 | GGPS1 (0.73) | GGPS1FDPSPTPN5PTPN1 | |
| SCHEMBL3360700 | 0.78 | GGPS1 (0.73) | GGPS1FDPSPTPN5PTPN1 | |
| SCHEMBL13458846 | 0.78 | GGPS1 (0.78) | GGPS1FDPSPTPN5PTPN1BTN3A1 | |
| SCHEMBL23752150 | 0.74 | GGPS1 (1.00) | GGPS1FDPSPTPN5PTPN1 | |
| SCHEMBL10880584 | 0.73 | FDPS (0.62) | GGPS1FDPSPTPN1BTN3A1PDE3A | |
| SCHEMBL271001 | 0.73 | FDPS (1.00) | GGPS1FDPSBTN3A1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687482-B2 | Bisphosphonate compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687482-B2 | Bisphosphonate compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-03-30 | — | — | US | disclosed |
| EP-2001486-A2 | BISPHOSPHONATE COMPOUNDS AND METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20070275931-A1 | BISPHOSPHONATE COMPOUNDS AND METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-11-29 | — | — | US | disclosed |
| US-20070275931-A1 | BISPHOSPHONATE COMPOUNDS AND METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-11-29 | — | — | US | disclosed |
| WO-2007109585-A2 | BISPHOSPHONATE COMPOUNDS AND METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275931-A1 | BISPHOSPHONATE COMPOUNDS AND METHODS | FDPS, GGPS1, FNTB | GGPS1 2/4885FDPS 1/4885PTPN5 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.