Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.64 |
| ▸ | POLH | Q9Y253 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | APEX1 | P27695 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 8/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | IP6K2 | Q9UHH9 | 4/20 | 0.57 |
| ▸ | XDH | P47989 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30527883 | 0.91 | MEN1 (0.67) | CYP3A4CYP2D6POLHKDM4EAPEX1 | |
| SCHEMBL30509121 | 0.86 | ABCB1 (0.56) | CYP3A4CYP2D6POLHKDM4EAPEX1 | |
| SCHEMBL5040391 | 0.82 | MEN1 (0.70) | CYP3A4CYP2D6POLHKDM4EAPEX1 | |
| SCHEMBL4104591 | 0.81 | MEN1 (0.64) | CYP3A4CYP2D6POLHKDM4EAPEX1 | |
| SCHEMBL11097926 | 0.81 | ESR1 (0.73) | CYP3A4CYP2D6KDM4EMEN1KMT2A | |
| SCHEMBL11244826 | 0.79 | MEN1 (0.52) | CYP3A4CYP2D6POLHKDM4EPOLB | |
| SCHEMBL22142507 | 0.79 | MEN1 (0.61) | CYP3A4CYP2D6POLHKDM4EAPEX1 | |
| SCHEMBL30684642 | 0.79 | CYP3A4 (0.78) | CYP3A4CYP2D6POLHKDM4EAPEX1 | |
| SCHEMBL2565483 | 0.79 | CYP3A4 (0.78) | CYP3A4CYP2D6POLHKDM4EAPEX1 | |
| SCHEMBL3051862 | 0.78 | GLO1 (0.58) | CYP3A4CYP2D6POLHKDM4EAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039679-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2010-04-08 | — | — | WO | disclosed |