Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 4-Aminophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 3/20 | 0.56 |
| ▸ | ESR2 known ✓ | Q92731 | 3/20 | 0.56 |
| ▸ | CA3 | P07451 | 4/20 | 0.68 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | CA6 | P23280 | 2/20 | 0.68 |
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | CASP1 | P29466 | 1/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA4 | P22748 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Aminophenol SCHEMBL27782121 | 0.92 | ALDH1A1 (0.72) | CA3CA14ALDH1A1CYP3A4CA6 | |
| 4-Aminophenol SCHEMBL27835004 | 0.89 | ALDH1A1 (0.77) | CA3CA14ALDH1A1CYP3A4CA6 | |
| Acetic Acid SCHEMBL7113664 | 0.89 | MAPT (0.53) | CA3CA14ALDH1A1CYP3A4CA6 | |
| Acetic Acid SCHEMBL8968769 | 0.89 | MAPT (0.53) | CA3CA14ALDH1A1CYP3A4CA6 | |
| Acetic Acid SCHEMBL2043001 | 0.89 | MAPT (0.53) | CA3CA14ALDH1A1CYP3A4CA6 | |
| 4-Aminophenol SCHEMBL28102190 | 0.86 | ALDH1A1 (0.93) | CA3CA14ALDH1A1CYP3A4CA6 | |
| Hydroquinone SCHEMBL1746628 | 0.86 | CA2 (0.58) | CA3CA14ALDH1A1CYP3A4CA6 | |
| Hydroquinone SCHEMBL2505159 | 0.86 | CA2 (0.58) | CA3CA14ALDH1A1CYP3A4CA6 | |
| 4-Aminophenol SCHEMBL31598822 | 0.85 | ALDH1A1 (0.62) | CA3CA14ALDH1A1CYP3A4CA6 | |
| 4-Aminophenol SCHEMBL28749694 | 0.85 | ALDH1A1 (0.62) | CA3CA14ALDH1A1CYP3A4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848815-B1 | ESTERASES FOR MONITORING PROTEIN BIOSYNTHESIS IN VITRO | UNIV BAYREUTH (DE) | 2010-05-19 | — | — | EP | claimed |
| US-11422106-B2 | Using 4-acetoxyphenol as a substrate for modular hydrolase biosensors | United States Government, as represented by the Administrator of the U.S. EPA (US) | 2022-08-23 | — | — | US | disclosed |
| US-20200264124-A1 | USING 4-ACETOXYPHENOL AS A SUBSTRATE FOR MODULAR HYDROLASE BIOSENSORS | US GOVERNMENT, AS REPRESENTED BY THE ADMINISTRATOR OF THE EPA | 2020-08-20 | — | — | US | disclosed |
| EP-0769573-B1 | Process for reducing aluminium corrosion and use of a corrosion inhibitor in antifreeze compositions | BP CHEM INT LTD (GB) | 2000-03-22 | — | — | EP | disclosed |
| EP-0769573-A1 | Anticorrosion agent and antifreeze composition containing the anticorrosion agent | BP Chemicals Limited (GB) | 1997-04-23 | — | — | EP | disclosed |