Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359372 | 0.90 | TGFBR1 (0.40) | BTKEGFRTGFBR1LCKJAK3 | |
| SCHEMBL3362516 | 0.86 | ZAP70 (0.47) | ZAP70BTKEGFRLRRK2LCK | |
| SCHEMBL3362890 | 0.85 | ZAP70 (0.39) | ZAP70BTKEGFRLRRK2AKT1 | |
| SCHEMBL3358405 | 0.84 | ZAP70 (0.46) | ZAP70BTKEGFRLRRK2AKT1 | |
| SCHEMBL3359505 | 0.83 | ZAP70 (0.47) | ZAP70BTKEGFRJAK3SYK | |
| SCHEMBL3360218 | 0.83 | ZAP70 (0.48) | ZAP70AKT1JAK3KIF18ASYK | |
| SCHEMBL3361973 | 0.83 | ZAP70 (0.47) | ZAP70LRRK2JAK3P2RX3SYK | |
| SCHEMBL3362937 | 0.83 | ZAP70 (0.48) | ZAP70BTKEGFRJAK3SYK | |
| SCHEMBL3359492 | 0.81 | ZAP70 (0.46) | ZAP70BTKEGFRJAK3KIF18A | |
| SCHEMBL1049067 | 0.81 | ZAP70 (0.60) | ZAP70LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |