Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508263 | 0.90 | ALDH1A1 (0.49) | ACHEBCL2A1MEN1KMT2ATP53 | |
| SCHEMBL508477 | 0.88 | BCL2A1 (0.45) | ACHEBCL2A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL508541 | 0.86 | ACHE (0.41) | ACHEBCL2A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL508540 | 0.86 | ACHE (0.41) | ACHEBCL2A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL509223 | 0.77 | BCL2A1 (0.56) | BCL2A1MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL508789 | 0.75 | MAPK13 (0.49) | BCL2A1MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL13363657 | 0.75 | MAPK13 (0.49) | BCL2A1MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL509598 | 0.75 | MAPK13 (0.48) | BCL2A1MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL508769 | 0.75 | MAPK13 (0.50) | ACHEBCL2A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL508768 | 0.75 | MAPK13 (0.50) | ACHEBCL2A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054107-A2 | KINASE KNOCKDOWN VIA ELECTROPHILICALLY ENHANCED INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2010-05-14 | — | — | WO | disclosed |