Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362595 | 0.89 | ZAP70 (0.48) | ZAP70SYKJAK2PTK2JAK3 | |
| SCHEMBL3359111 | 0.89 | ZAP70 (0.52) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL3362403 | 0.89 | ZAP70 (0.68) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL3362028 | 0.88 | ZAP70 (0.49) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL3358601 | 0.86 | ZAP70 (0.49) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL3362351 | 0.85 | ZAP70 (0.49) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL3358710 | 0.85 | JAK2 (0.45) | ZAP70SYKJAK2PTK2JAK3 | |
| SCHEMBL3360188 | 0.85 | ZAP70 (0.48) | ZAP70SYKJAK3EGFRLCK | |
| SCHEMBL3358518 | 0.85 | ZAP70 (0.53) | ZAP70SYKJAK3EGFR | |
| SCHEMBL3359391 | 0.84 | ZAP70 (0.44) | ZAP70SYKJAK3EGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |