Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361210 | 0.90 | SRC (0.42) | SYKJAK2EGFRSRCKDR | |
| SCHEMBL3359957 | 0.88 | SYK (0.43) | ZAP70SYKJAK2EGFRSRC | |
| SCHEMBL3359360 | 0.84 | SYK (0.40) | SYKJAK2EGFRSRCCDK1 | |
| SCHEMBL3362294 | 0.83 | BCHE (0.45) | SYKJAK2EGFRSRCCDK1 | |
| SCHEMBL3359856 | 0.81 | ZAP70 (0.40) | ZAP70SYK | |
| SCHEMBL1049849 | 0.80 | ZAP70 (0.68) | ZAP70SYKJAK2 | |
| SCHEMBL3359058 | 0.78 | ZAP70 (0.42) | ZAP70SYKJAK2EGFR | |
| SCHEMBL3362887 | 0.77 | ZAP70 (0.46) | ZAP70SYKJAK2EGFRKDR | |
| SCHEMBL3358947 | 0.77 | CYP2C19 (0.40) | ZAP70SYKJAK2EGFRKDR | |
| SCHEMBL3359028 | 0.77 | ZAP70 (0.41) | ZAP70SYKJAK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |